Polymorphism of promotor region of the tumor necrosis factor-alpha gene in patients with viral hepatitis C

Study of the pathogenesis of viral hepatitis C is of primary importance because of persistence of this virus and high incidence of chronic course of this disease, and as a consequence, development of cirrhotic and neoplastic processes in the liver determining high mortality from this condition. Proi...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2004-03, Vol.137 (3), p.270-272
Main Authors: Smol'nikova, M V, Avdoshina, V V, Tolokonskaya, N P, Kolesnikov, A P, Konenkov, V I
Format: Article
Language:English
Subjects:
Alleles
Case-Control Studies
Gene Frequency
Genotype
Hepatitis C, Chronic - genetics
Hepatitis C, Chronic - immunology
Humans
Polymorphism, Genetic
Promoter Regions, Genetic
Siberia
Tumor Necrosis Factor-alpha - genetics
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Summary:Study of the pathogenesis of viral hepatitis C is of primary importance because of persistence of this virus and high incidence of chronic course of this disease, and as a consequence, development of cirrhotic and neoplastic processes in the liver determining high mortality from this condition. Proinflammatory cytokines, in particular, tumor necrosis factor, play an important role in the development of these pathological processes. The content of tumor necrosis factor in the circulating blood plasma and hepatocytes increases in acute and chronic hepatitis C. It seems that the capacity of cells to produce proinflammatory IL in high or low levels spontaneously or after antigenic stimulation largely determines the outcome of infectious process in contact with the virus.
ISSN:0007-4888
DOI:10.1023/B:BEBM.0000031567.09958.bd