Thromboelastography used to assess coagulation during treatment with molecular adsorbent recirculating system

:  Coagulopathy is a life‐threatening complication of liver cirrhosis. We describe the effect of molecular adsorbent recirculating system (MARS), a cell‐free dialysis technique, on the blood coagulation of cirrhotic patients. From February 2002 to July 2002, nine patients – five males (55.5%) and fo...

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Bibliographic Details
Published in:Clinical transplantation 2004-08, Vol.18 (4), p.365-371
Main Authors: Doria, Cataldo, Mandalà, Lucio, Smith, Jan D, Caruana, Giuseppe, Scott, Victor L, Gruttadauria, Salvatore, Magnone, Mario, Marino, Ignazio R
Format: Article
Language:English
Subjects:
Aged
albumin
artificial liver
Biological and medical sciences
bleeding
Blood Coagulation
Blood Coagulation Disorders - etiology
Cardiology. Vascular system
cirrhosis
dialysis
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Liver Cirrhosis - physiopathology
Liver Cirrhosis - therapy
Liver Failure, Acute - therapy
Liver, Artificial
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Membranes, Artificial
Middle Aged
Other diseases. Semiology
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Thrombelastography
transplantation
Ultrafiltration
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Summary::  Coagulopathy is a life‐threatening complication of liver cirrhosis. We describe the effect of molecular adsorbent recirculating system (MARS), a cell‐free dialysis technique, on the blood coagulation of cirrhotic patients. From February 2002 to July 2002, nine patients – five males (55.5%) and four females (44.4%), age 47–70 yr (median 56) – underwent 12 courses (4–7 sessions each) of MARS. Patients were treated for the following indications: six (66.6%) acute‐on‐chronic hepatic failure, three (33.3%) intractable pruritus. Platelet count, prothrombin time (PT), international standardized ratio and thromboelastography were measured before and after each MARS session. Coagulation factors II, V, VII, VIII, IX, X, XI, XII, XIII, von Willebrand, lupus anticoagulant, protein C, protein S, antithrombin III, plasminogen, α2 antiplasmin, d‐dimer, fibrin monomers, complement, and C1 inactivator were measured before and at the end of each MARS treatment. We found a statistically significant difference (p 
ISSN:0902-0063
1399-0012
DOI:10.1111/j.1399-0012.2004.00172.x