Prognostic Significance of Dysadherin and E-cadherin Expression in Patients with Head and Neck Cancer Treated by Radiation Therapy

Background: The aim of this study was to evaluate the impact of dysadherin and E-cadherin expression on the clinical outcomes, including the treatment outcomes and recurrence pattern, in patients with head and neck cancer. Patients and Methods: Tumor specimens were obtained from 48 head and neck can...

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Published in:Anticancer research 2008-11, Vol.28 (6B), p.3859-3864
Main Authors: MURAMATSU, Hiroyuki, AKIMOTO, Tetsuo, MAEBAYASHI, Katsuya, KITA, Midori, MITSUHASHI, Norio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cadherins - biosynthesis
Female
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - radiotherapy
Humans
Immunohistochemistry
Male
Medical sciences
Membrane Glycoproteins - biosynthesis
Middle Aged
Neoplasm Proteins - biosynthesis
Neoplasm Recurrence, Local - metabolism
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Prognosis
Survival Rate
Treatment Outcome
Tumors
Young Adult
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Summary:Background: The aim of this study was to evaluate the impact of dysadherin and E-cadherin expression on the clinical outcomes, including the treatment outcomes and recurrence pattern, in patients with head and neck cancer. Patients and Methods: Tumor specimens were obtained from 48 head and neck cancer patients who were treated by radiation therapy and the specimens were immunohistochemically stained for dysadherin and E-cadherin. The expressions were graded according to the percentage area occupied by cancer cells showing positive staining for E-cadherin and dysadherin as follows: grade 0, less than 10%; grade 1, 10-50%; grade 2, more than 50% . The correlations between the expression of E-cadherin and dysadherin and the clinical outcomes, including the treatment outcomes and recurrence pattern, were analyzed. Results: The complete response (CR) rate in the patients with a dysadherin expression grade of 0 or 1 was 70% and that in the patients with dysadherin expression grade of 2 was 38%; the difference was significant (p
ISSN:0250-7005
1791-7530