Antioxidant activities and lipid lowering effects of isoflavone in male rabbits

• Published in: Food and chemical toxicology 2004-09, Vol.42 (9), p.1497-1503
• Main Authors: Yousef, Mokhtar I., Kamel, Kamel I., Esmail, Alshaimaa M., Baghdadi, Hoda H.
• Format: Article
• Language: English
• Subjects: Animals; antioxidant activity; antioxidants; Antioxidants - pharmacology; Biological and medical sciences; blood lipids; cardioprotective effect; cholesteremic effect; dosage; dose response; Dose-Response Relationship, Drug; Free radicals; Free Radicals - blood; Glutathion S-transferase; glutathione transferase; Glutathione Transferase - blood; Hypolipidemic Agents - pharmacology; Isoflavones; Isoflavones - pharmacology; lipid peroxidation; Lipid Peroxidation - drug effects; Lipids; Lipoprotein; lipoproteins; Lipoproteins - blood; Male; Medical sciences; nutrient intake; plant extracts; Rabbits; reactive oxygen species; soybean products; Thiobarbituric Acid Reactive Substances - analysis; thiobarbituric acid-reactive substances; Toxicology
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2004.04.012

Dietary flavonoids appear to play a role in the prevention of a number of chronic diseases such as cancer and cardiovascular disease and the soy isoflavones have been the focus of particular. Consumption of soy isoflavones may reduce the risk of cardiovascular disease both through reduction in serum lipids and by the antioxidant properties. We have therefore investigate the effects of either 2.5 or 5 mg/kg B.W. doses of isoflavones on the levels of free radicals, lipids and lipoproteins in male New Zealand White rabbits. Animals were orally given 2.5 or 5 mg/kg B.W. doses of isoflavones. The tested doses were given to rabbits every other day for 13 weeks. Treatment with isoflavones caused significant ( P