Improvement of diastolic function after regression of left ventricular hypertrophy

To evaluate the diastolic function after regression of left ventricular hypertrophy, in mild to moderate hypertension treated with angiotensin converting enzyme(ACE) inhibitor and, if necessary, with a diuretic. Ninety-eight hypertensive patients with left ventricular hypertrophy (LVH) and abnormal...

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Published in:Archivos de cardiología de México 2008-10, Vol.78 (4), p.392-399
Main Authors: Teniente-Valente, Raúl, Solorio, Sergio, Vargas-Salado, Enrique, Aguirre-Vázquez, Carlos, Hernández-González, Martha A, Olvera-Lopez, José Antonio, Rodríguez-Mariscal, Leticia, Luna-Ruiz, Miguel Angel, Guillén Contreras, José Manuel, Murillo Ortiz, Blanca Olivia
Format: Article
Language:English
Subjects:
Adult
Aged
Antihypertensive Agents - therapeutic use
Blood Pressure - drug effects
Blood Pressure - physiology
Captopril - therapeutic use
Chlorthalidone - therapeutic use
Diastole - drug effects
Diastole - physiology
Female
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Hypertrophy, Left Ventricular - drug therapy
Hypertrophy, Left Ventricular - physiopathology
Male
Middle Aged
Prospective Studies
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Summary:To evaluate the diastolic function after regression of left ventricular hypertrophy, in mild to moderate hypertension treated with angiotensin converting enzyme(ACE) inhibitor and, if necessary, with a diuretic. Ninety-eight hypertensive patients with left ventricular hypertrophy (LVH) and abnormal left ventricle diastolic function indexes received captopril (Capotena) 50 to 200 mg/day plus chlortalidone during 12 months to reach blood pressure control, defined as a diastolic blood pressure < or =90 and systolic blood pressure < or =140 mm Hg. Left ventricular (LV) mass index was calculated by M mode and two-dimensional echocardiography, and left ventricular diastolic function was assessed by transmitral pulsed Doppler ultrasound every 3 months. Sixty-three patients were women and 35 were men, mean age was 53.4 +/- 8.4 years (range 34-70). Thirty-six patients had mild (36.7%) and 62 (63.3%) moderate hypertension. Treatment reduced significantly both systolic pressure from 165 +/- 13 to 137 +/- 12.9 mm Hg (p
ISSN:1405-9940