Enhancement of the resolution of surface plasmon resonance biosensors by control of the size and distribution of nanoparticles

A new resolution-enhanced surface plasmon resonance (SPR) biosensor offers a tenfold improvement in resolution compared with conventional SPR biosensors in the detection of the surface coverage of biomaterials. The proposed optical biosensor, based on the attenuated total-reflection method, excites...

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Bibliographic Details
Published in:Optics letters 2004-06, Vol.29 (12), p.1390-1392
Main Authors: Chen, S J, Chien, F C, Lin, G Y, Lee, K C
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Crystallization - methods
Equipment Design
Equipment Failure Analysis
Gold - chemistry
Nanotechnology - methods
Nanotubes - chemistry
Nanotubes - ultrastructure
Oligonucleotides - analysis
Oligonucleotides - chemistry
Particle Size
Reproducibility of Results
Sensitivity and Specificity
Silver - chemistry
Surface Plasmon Resonance - instrumentation
Surface Plasmon Resonance - methods
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Summary:A new resolution-enhanced surface plasmon resonance (SPR) biosensor offers a tenfold improvement in resolution compared with conventional SPR biosensors in the detection of the surface coverage of biomaterials. The proposed optical biosensor, based on the attenuated total-reflection method, excites both the surface plasmons and particle plasmons to enhance the local electromagnetic field by control of the size and volume fraction of embedded Au nanoparticles to increase the resolution of the device. The SPR biosensor design is based on the Maxwell-Garnett model and the Fresnel equations, and the device is fabricated with a cosputtering deposition system.
ISSN:0146-9592
1539-4794
DOI:10.1364/ol.29.001390