DNA vaccines against human immunodeficiency virus type 1

Development of a vaccine against human immunodeficiency virus type 1 (HIV‐1) is the main hope for controlling the acquired immunodeficiency syndrome pandemic. An ideal HIV vaccine should induce neutralizing antibodies, CD4+ helper T cells, and CD8+ cytotoxic T cells. While the induction of broadly n...

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Bibliographic Details
Published in:Immunological reviews 2004-06, Vol.199 (1), p.144-155
Main Authors: Estcourt, Marie J., McMichael, Andrew J., Hanke, Tomás̆
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - prevention & control
AIDS Vaccines - genetics
AIDS Vaccines - immunology
Antigen Presentation - immunology
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
CpG Islands - genetics
CpG Islands - immunology
HIV-1 - immunology
Human immunodeficiency virus 1
Humans
Plasmids - genetics
Plasmids - immunology
Vaccines, DNA - genetics
Vaccines, DNA - immunology
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Summary:Development of a vaccine against human immunodeficiency virus type 1 (HIV‐1) is the main hope for controlling the acquired immunodeficiency syndrome pandemic. An ideal HIV vaccine should induce neutralizing antibodies, CD4+ helper T cells, and CD8+ cytotoxic T cells. While the induction of broadly neutralizing antibodies remains a highly challenging goal, there are a number of technologies capable of inducing potent cell‐mediated responses in animal models, which are now starting to be tested in humans. Naked DNA immunization is one of them. This review focuses on the stimulation of HIV‐specific T cells and discusses in the context of the current ‘state‐of‐art’ of DNA vaccines, the areas where this technology might assist either alone or as a part of more complex vaccine formulations in the HIV vaccine development.
ISSN:0105-2896
1600-065X
DOI:10.1111/j.0105-2896.2004.00151.x