Alcohol consumption and risk of adult-onset acute myeloid leukemia: results from a Los Angeles County case-control study

Few studies have examined the role of alcohol consumption in risk of adult acute myeloid leukemia (AML). Two previous case-control studies resulted in inconsistent findings. We report data from a Los Angeles County population-based case-control study in which 164 matched case-control pairs were aske...

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Bibliographic Details
Published in:Leukemia research 2004-09, Vol.28 (9), p.927-931
Main Authors: Pogoda, Janice M, Nichols, Peter W, Preston-Martin, Susan
Format: Article
Language:English
Subjects:
Acute Disease
Acute myeloid leukemia
Adult
Age of Onset
Aged
Alcohol
Alcohol Drinking - adverse effects
Case-Control Studies
FAB type
Female
Humans
Leukemia, Myeloid - etiology
Los Angeles - epidemiology
Male
Middle Aged
Odds Ratio
Protective Agents - pharmacology
Risk Factors
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Summary:Few studies have examined the role of alcohol consumption in risk of adult acute myeloid leukemia (AML). Two previous case-control studies resulted in inconsistent findings. We report data from a Los Angeles County population-based case-control study in which 164 matched case-control pairs were asked about lifetime history of alcohol consumption and 136 cases were subtyped according to the French-American-British (FAB) criteria. Estimated categorical odds ratios (OR) adjusted for smoking and education were suggestive of a possible protective effect but trend tests were non-significant. Analyses by FAB subtype did not reveal subtype-specific associations but generally suffered from lack of power. Larger studies are needed to more thoroughly investigate the relationship between alcohol consumption and AML risk.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2004.01.007