Analysis and purification of alcohol-sensitive chiral compounds using 2,2,2-trifluoroethanol as a modifier in supercritical fluid chromatography

2,2,2-Trifluoroethanol (TFE) is evaluated as an alternative modifier for the analysis and purification of alcohol-sensitive chiral compounds using supercritical fluid chromatography (SFC). Four chiral compounds, selected for their sensitivity to alcohols, in addition to a variety of standard chiral...

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Bibliographic Details
Published in:Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2008-11, Vol.875 (1), p.237-242
Main Authors: Byrne, Neal, Hayes-Larson, Eleanor, Liao, Wei-Wei, Kraml, Christina M.
Format: Article
Language:English
Subjects:
Alcohol-sensitive compounds
Anhydrides - isolation & purification
Chiral separations
Chromatography, Supercritical Fluid - methods
Fluorinated solvents
Glutarates - isolation & purification
Pharmaceutical Preparations - isolation & purification
SFC
Stereoisomerism
TFE
Trifluoroethanol - chemistry
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Summary:2,2,2-Trifluoroethanol (TFE) is evaluated as an alternative modifier for the analysis and purification of alcohol-sensitive chiral compounds using supercritical fluid chromatography (SFC). Four chiral compounds, selected for their sensitivity to alcohols, in addition to a variety of standard chiral compounds were analyzed by SFC using TFE with polysaccharide and Pirkle-type chiral stationary phases (CSPs) to produce selectivities ( α) and resolutions ( R s) as high as 1.4 and 7.2. A preparative isolation of 2-phenylglutaric anhydride was achieved using TFE as the mobile phase modifier to produce clean enantiomers.
ISSN:1570-0232
1873-376X
DOI:10.1016/j.jchromb.2008.06.057