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Analysis and purification of alcohol-sensitive chiral compounds using 2,2,2-trifluoroethanol as a modifier in supercritical fluid chromatography
2,2,2-Trifluoroethanol (TFE) is evaluated as an alternative modifier for the analysis and purification of alcohol-sensitive chiral compounds using supercritical fluid chromatography (SFC). Four chiral compounds, selected for their sensitivity to alcohols, in addition to a variety of standard chiral...
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| Published in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2008-11, Vol.875 (1), p.237-242 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c392t-8fa0860dfeb77cb5de171ad953ec83f22480b64991a36568e346f5ce6d07e8183 |
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| container_end_page | 242 |
| container_issue | 1 |
| container_start_page | 237 |
| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
| container_volume | 875 |
| creator | Byrne, Neal Hayes-Larson, Eleanor Liao, Wei-Wei Kraml, Christina M. |
| description | 2,2,2-Trifluoroethanol (TFE) is evaluated as an alternative modifier for the analysis and purification of alcohol-sensitive chiral compounds using supercritical fluid chromatography (SFC). Four chiral compounds, selected for their sensitivity to alcohols, in addition to a variety of standard chiral compounds were analyzed by SFC using TFE with polysaccharide and Pirkle-type chiral stationary phases (CSPs) to produce selectivities (
α) and resolutions (
R
s) as high as 1.4 and 7.2. A preparative isolation of 2-phenylglutaric anhydride was achieved using TFE as the mobile phase modifier to produce clean enantiomers. |
| doi_str_mv | 10.1016/j.jchromb.2008.06.057 |
| format | article |
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α) and resolutions (
R
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α) and resolutions (
R
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α) and resolutions (
R
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| fulltext | fulltext |
| identifier | ISSN: 1570-0232 |
| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-11, Vol.875 (1), p.237-242 |
| issn | 1570-0232 1873-376X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66683626 |
| source | ScienceDirect Freedom Collection |
| subjects | Alcohol-sensitive compounds Anhydrides - isolation & purification Chiral separations Chromatography, Supercritical Fluid - methods Fluorinated solvents Glutarates - isolation & purification Pharmaceutical Preparations - isolation & purification SFC Stereoisomerism TFE Trifluoroethanol - chemistry |
| title | Analysis and purification of alcohol-sensitive chiral compounds using 2,2,2-trifluoroethanol as a modifier in supercritical fluid chromatography |
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