Serum levels of antibodies to Chlamydia pneumoniae and human HSP60 in giant cell arteritis patients

To measure the serum levels of IgG anti-Chlamydia pneumoniae (C. pneumoniae) and human heat shock protein (hHSP) 60 antibodies in patients with active giant cell arteritis (GCA) and to determine whether such levels decrease with corticosteroid therapy and remission of symptoms. IgG anti-C. pneumonia...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2008-11, Vol.26 (6), p.1107-1110
Main Authors: LOPEZ-HOYOS, M, ALVAREZ, L, RUIZ SOTO, M, BLANCO, R, BARTOLOME, M. José, MARTINEZ-TABOADA, V. M
Format: Article
Language:English
Subjects:
Aged
Antibodies, Bacterial - blood
Autoantibodies - blood
Biological and medical sciences
Chaperonin 60 - immunology
Chlamydophila Infections - immunology
Chlamydophila pneumoniae - immunology
Diseases of the osteoarticular system
Female
Giant Cell Arteritis - drug therapy
Giant Cell Arteritis - epidemiology
Giant Cell Arteritis - immunology
Humans
Immunoglobulin G - blood
Inflammatory joint diseases
Male
Medical sciences
Polymyalgia Rheumatica - drug therapy
Polymyalgia Rheumatica - epidemiology
Polymyalgia Rheumatica - immunology
Remission Induction
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Seroepidemiologic Studies
Steroids - therapeutic use
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Summary:To measure the serum levels of IgG anti-Chlamydia pneumoniae (C. pneumoniae) and human heat shock protein (hHSP) 60 antibodies in patients with active giant cell arteritis (GCA) and to determine whether such levels decrease with corticosteroid therapy and remission of symptoms. IgG anti-C. pneumoniae and anti-hHSP60 antibodies were quantified by commercial and in-house ELISA tests, respectively, in serum samples from 17 GCA patients, 39 polymyalgia rheumatica (PMR) patients and 23 age-matched healthy subjects. Serum IgG anti-hHSP60, but not anti-C. pneumoniae, antibodies were significantly increased in GCA patients in comparison with PMR patients or healthy controls. After steroid therapy, both anti-hHSP60 and -C. pneumoniae antibodies decreased significantly in both groups of patients. Although some infectious agents have been suggested to participate in GCA pathogenesis, our data do not suggest that C. pneumoniae might be one of them. The production of anti-hHSP60 antibodies is shared in GCA with other systemic diseases and may be triggered by unknown infectious agents and/or other inflammatory factors.
ISSN:0392-856X
1593-098X