D-Amino acid oxidase: Physiological role and applications

D-Amino acids play a key role in regulation of many processes in living cells. FAD-dependent D-amino acid oxidase (DAAO) is one of the most important enzymes responsible for maintenance proper level of D-amino acids. The most interesting and important data for regulation of the nervous system, hormo...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry (Moscow) 2008-12, Vol.73 (13), p.1511-1518
Main Authors: Khoronenkova, S. V, Tishkov, V. I
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids - metabolism
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
D-Amino-Acid Oxidase - biosynthesis
D-Amino-Acid Oxidase - chemistry
D-Amino-Acid Oxidase - metabolism
Enzymes
Eukaryotic Cells - metabolism
Humans
Life Sciences
Microbiology
Oxidation
Review
Saccharomycetales - enzymology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:D-Amino acids play a key role in regulation of many processes in living cells. FAD-dependent D-amino acid oxidase (DAAO) is one of the most important enzymes responsible for maintenance proper level of D-amino acids. The most interesting and important data for regulation of the nervous system, hormone secretion, and other processes by D-amino acids as well as development of different diseases under changed DAAO activity are presented. The mechanism of regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects. Use of DAAO for diagnostic and therapeutic purposes is also considered.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297908130105