The Biphasic Relationship between Regional Brain Senile Plaque and Neurofibrillary Tangle Distributions: Modification by Age, Sex, and APOE Polymorphism

: Epidemiologic studies indicate that elderly women are at higher risk for Alzheimer disease compared to men. In order to pathologically verify this result, the extent of AD brain lesions (NFT and SP) was compared for men and women at each age, that is, at each decade from 25 years to 95 years, in a...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2004-06, Vol.1019 (1), p.24-28
Main Authors: CORDER, ELIZABETH H., GHEBREMEDHIN, ESTIFANOS, TAYLOR, MILES G., THAL, DIETMAR R., OHM, THOMAS G., BRAAK, HEIKO
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
aging
Alleles
Alzheimer disease
apolipoprotein E
Apolipoproteins E - genetics
brain
Brain - pathology
Female
gender
Humans
Male
Middle Aged
neurofibrillary tangles
Neurofibrillary Tangles - pathology
Neurons - metabolism
neuropathology
Plaque, Amyloid - pathology
Polymorphism, Genetic
senile plaques
Sex Factors
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Summary:: Epidemiologic studies indicate that elderly women are at higher risk for Alzheimer disease compared to men. In order to pathologically verify this result, the extent of AD brain lesions (NFT and SP) was compared for men and women at each age, that is, at each decade from 25 years to 95 years, in a large sample of > 5000 routine autopsy cases. Women had more affected brain regions beginning in late middle age. They also had more extensive SP depositions throughout the brain compared to men at each early NFT stage I, II, and III. At later NFT stages IV, V, and VI both men and women had extensive SP deposits. The gender gap in SPs at early NFT stages was large and specific to women who carried the APOE4 allele (P < .001) and in addition to the acceleration in NFT stage also found for APOE4+ women.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1297.005