Comparison of neointimal formation in polymer-free paclitaxel stents versus stainless stents (from the ASPECT and ELUTES randomized clinical trials)

The investigators examined 326 pairs of angiograms from 2 randomized dose-finding (0.2 to 3.1 μg paclitaxel/mm 2 of stent surface area) clinical trials of polymer-free paclitaxel-eluting stents in de novo lesions (the ASian Paclitaxel-Eluting stent Clinical Trial [ASPECT] and the European evaLUation...

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Bibliographic Details
Published in:The American journal of cardiology 2004-07, Vol.94 (2), p.199-201
Main Authors: Kałuża, Grzegorz L, Gershlick, Anthony H, Park, Seung-Jung, De Scheerder, Ivan, Chevalier, Bernard, Camenzind, Edoardo, Goy, Jean-Jacques, Missault, Luc, Reifart, Nicolaus, Vrints, Christiaan, Urban, Philip, Shim, Won Heum, Ho, David Sai Wah, Fearnot, Neal E, Voorhees, William D, Raizner, Albert E
Format: Article
Language:English
Subjects:
Angiogenesis Inhibitors - administration & dosage
Cardiology
Clinical trials
Comparative analysis
Coronary Angiography
Coronary Restenosis - prevention & control
Dose-Response Relationship, Drug
Humans
Hyperplasia - prevention & control
Paclitaxel - administration & dosage
Polymers
Prosthesis Design
Randomized Controlled Trials as Topic
Stainless Steel
Stents
Tunica Intima - pathology
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Summary:The investigators examined 326 pairs of angiograms from 2 randomized dose-finding (0.2 to 3.1 μg paclitaxel/mm 2 of stent surface area) clinical trials of polymer-free paclitaxel-eluting stents in de novo lesions (the ASian Paclitaxel-Eluting stent Clinical Trial [ASPECT] and the European evaLUation of Taxol Eluting Stent [ELUTES]). A dose-dependent effect was observed: the largest dose of paclitaxel in the 2 trials resulted in a significantly larger proportion of lesions at follow-up with
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2004.03.063