A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori

A genome-wide analysis of innate immunity-related genes and gene families was conducted using the silkworm, Bombyx mori. We identified orthologs for a large number of genes involved in insect immunity that have been reported from Drosophila melanogaster (Diptera), Anopheles gambiae (Diptera), Apis m...

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Bibliographic Details
Published in:Insect biochemistry and molecular biology 2008-12, Vol.38 (12), p.1087-1110
Main Authors: Tanaka, Hiromitsu, Ishibashi, Jun, Fujita, Kosuke, Nakajima, Yoshiro, Sagisaka, Aki, Tomimoto, Kazuya, Suzuki, Noriko, Yoshiyama, Mikio, Kaneko, Yoichi, Iwasaki, Takashi, Sunagawa, Tomoya, Yamaji, Kayoko, Asaoka, Ai, Mita, Kazuei, Yamakawa, Minoru
Format: Article
Language:English
Subjects:
Animals
Anopheles gambiae
Apis
Apis mellifera
bacterial infections
Bombyx - genetics
Bombyx - immunology
Bombyx mori
Coleoptera
Comparative genomics
Diptera
Drosophila melanogaster
evolution
Gene evolution
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Gene family
genes
Genes, Insect - immunology
genome
Genome, Insect
genomics
Hymenoptera
Immunity, Innate - genetics
immunity-related genes
Insect immunity
Lepidoptera
molecular sequence data
multigene family
Multigene Family - immunology
Selection, Genetic
sequence homology
Signaling pathways
Tribolium castaneum
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Summary:A genome-wide analysis of innate immunity-related genes and gene families was conducted using the silkworm, Bombyx mori. We identified orthologs for a large number of genes involved in insect immunity that have been reported from Drosophila melanogaster (Diptera), Anopheles gambiae (Diptera), Apis mellifera (Hymenoptera) and Tribolium castaneum (Coleoptera). B. mori has a unique recognition gene and antimicrobial peptide genes that are not present in the Drosophila, Anopheles, Apis and Tribolium genomes, suggesting a lineage-specific gene evolution for lepidopteran insects. The comparative analysis of the insect immune repertoires indicated a dynamic and flexible gene expansion in recognition, modulation and effector mechanisms due to different selection pressures. Differential gene regulation by different bacterial species was found in PGRP and Serpin genes, suggesting that Bombyx has a highly selective gene regulation system depending on bacterial species.
ISSN:0965-1748
1879-0240
DOI:10.1016/j.ibmb.2008.09.001