Non-specific stress-reaction as indicator of radiosensitivity

The data presented demonstrate possible personal radiosensitivity prognosis according to the immobilization stress response (animal model). It was demonstrated on the Wistar rats that in radiosensitive animals initial oxidative metabolism parameters were higher than in radioresistant ones, and proox...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2008, Vol.54 (6), p.72-78
Main Authors: Hanzha, O B, Rodionova, N K, Dolyns'kyĭ, H A, Kostiukova, L V, Druzhyna, M O
Format: Article
Language:Ukrainian
Subjects:
Animals
Bone Marrow Cells - metabolism
Bone Marrow Cells - radiation effects
Catalase - blood
Leukocytes - metabolism
Leukocytes - radiation effects
Male
Oxidative Stress - radiation effects
Radiation Tolerance
Rats
Rats, Wistar
Restraint, Physical
Stress, Psychological - blood
Stress, Psychological - etiology
Stress, Psychological - metabolism
Time Factors
X-Rays
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Summary:The data presented demonstrate possible personal radiosensitivity prognosis according to the immobilization stress response (animal model). It was demonstrated on the Wistar rats that in radiosensitive animals initial oxidative metabolism parameters were higher than in radioresistant ones, and prooxidant-antioxidant balance alteration after non-radiation stress were more evident and kept for a longer period. Those animals had had limphopenia and neutrophilosis. The differences in the response types between radiosensitive and radioresistant animals were due to the blood system reserve abilities, as well as the state of natural mature cells depot, and antioxidant defence enzymes.
ISSN:2522-9028