New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Part 3: 7beta-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins bearing 4-[3-(aminoalkyl)-ureido]-1-pyridinium at C-3

Among the prepared C-3' substituted-pyridinium cephalosporins, a series of 7beta-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins bearing 4-[3-(aminoalkyl)-ureido]-1-pyridinium at C-3' showed highly potent antibacterial activity against MRSA and Pseudomonas aerugin...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2004-08, Vol.12 (15), p.4221-4231
Main Authors: Yoshizawa, Hidenori, Kubota, Tadatoshi, Itani, Hikaru, Minami, Kyoji, Miwa, Hideaki, Nishitani, Yasuhiro
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Cephalosporins - chemical synthesis
Cephalosporins - chemistry
Cephalosporins - pharmacology
Methicillin Resistance
Microbial Sensitivity Tests
Molecular Structure
Pseudomonas aeruginosa - drug effects
Pyridinium Compounds - chemical synthesis
Pyridinium Compounds - chemistry
Pyridinium Compounds - pharmacology
Staphylococcus aureus - drug effects
Structure-Activity Relationship
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Summary:Among the prepared C-3' substituted-pyridinium cephalosporins, a series of 7beta-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-ethoxyiminoacetamido] cephalosporins bearing 4-[3-(aminoalkyl)-ureido]-1-pyridinium at C-3' showed highly potent antibacterial activity against MRSA and Pseudomonas aeruginosa.
ISSN:0968-0896