CD8 + T-cell memory: only the good ones last

Generating long-lasting, protective CD8 + T-cell memory via vaccination is critical for combating infectious diseases. Advances in the past year have provided many new insights into how memory CD8 + T cells are generated. It is now recognized that CD8 + T cells differentiate from ‘effector memory’ c...

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Bibliographic Details
Published in:Current opinion in immunology 2004-08, Vol.16 (4), p.451-455
Main Authors: Northrop, John K, Shen, Hao
Format: Article
Language:English
Subjects:
Animals
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cell Differentiation - immunology
Communicable Diseases - immunology
Humans
Immunologic Memory
Vaccination
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Summary:Generating long-lasting, protective CD8 + T-cell memory via vaccination is critical for combating infectious diseases. Advances in the past year have provided many new insights into how memory CD8 + T cells are generated. It is now recognized that CD8 + T cells differentiate from ‘effector memory’ cells into ‘central memory’ cells, which are stably maintained and confer superior protective immunity. Furthermore, CD4 + T-cell help plays an important role in guiding the differentiation of CD8 + T cells into long-lasting, functional memory. These findings have important implications for developing vaccine strategies that induce high-quality CD8 + T-cell memory, not just high quantity.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2004.05.004