Cyclic AMP-Induced Repair of Zebrafish Spinal Circuits

Neurons in the human central nervous system (CNS) are unable to regenerate, as a result of both an inhibitory environment and their inherent inability to regrow. In contrast, the CNS environment in fish is permissive for growth, yet some neurons still cannot regenerate. Fish thus offer an opportunit...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2004-07, Vol.305 (5681), p.254-258
Main Authors: Bhatt, Dimple H., Otto, Stefanie J., Depoister, Brett, Fetcho, Joseph R.
Format: Article
Language:English
Subjects:
Anatomy
Animal behavior
Animals
Axons
Axons - drug effects
Axons - physiology
Biological and medical sciences
Brain diseases
Bucladesine - pharmacology
Calcium
Calcium - metabolism
Care and treatment
Central nervous system
Cyclic AMP - analogs & derivatives
Cyclic AMP - pharmacology
Danio rerio
Development. Senescence. Regeneration. Transplantation
Dyes
Electroporation
Environment
Escape Reaction
Fish
Fluorescent Dyes
Freshwater
Fundamental and applied biological sciences. Psychology
Injuries
Interneurons - physiology
Lesions
Microscopy, Confocal
Molecules
Nerve Regeneration
Nervous system
Neurons
Neurons - drug effects
Neurons - physiology
Properties
Regeneration
Rhodamines
Spinal cord
Spinal Cord - cytology
Spinal Cord Injuries - drug therapy
Spinal Cord Injuries - physiopathology
Vehicles
Vertebrates: nervous system and sense organs
Zebrafish
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Description
Summary:Neurons in the human central nervous system (CNS) are unable to regenerate, as a result of both an inhibitory environment and their inherent inability to regrow. In contrast, the CNS environment in fish is permissive for growth, yet some neurons still cannot regenerate. Fish thus offer an opportunity to study molecules that might surmount the intrinsic limitations they share with mammals, without the complication of an inhibitory environment. We show by in vivo imaging in zebrafish that post-injury application of cyclic adenosine monophosphate can transform severed CNS neurons into ones that regenerate and restore function, thus overcoming intrinsic limitations to regeneration in a vertebrate.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1098439