Therapy Control in Oncology by Circulating Nucleosomes

: The courses of circulating nucleosomes in the serum of patients with various solid tumors correlate with the clinical outcome after chemo‐ and radiotherapy. Already during the initial phase of treatment they showed considerable alterations consisting of a rapid increase followed by a decrease duri...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2004-06, Vol.1022 (1), p.211-216
Main Authors: HOLDENRIEDER, S, STIEBER, P
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Apoptosis
chemotherapy
DNA - blood
early prediction
Humans
Kinetics
monitoring
Neoplasm Staging
Neoplasms - blood
Neoplasms - drug therapy
Neoplasms - pathology
nucleosomes
Nucleosomes - chemistry
Nucleosomes - metabolism
Remission Induction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:: The courses of circulating nucleosomes in the serum of patients with various solid tumors correlate with the clinical outcome after chemo‐ and radiotherapy. Already during the initial phase of treatment they showed considerable alterations consisting of a rapid increase followed by a decrease during the first therapeutic week. Among patients with advanced lung cancer undergoing chemotherapy, those patients who responded to therapy exhibited less pronounced increases and more complete decreases compared to those patients with insufficient response. In addition, response to therapy was correlated with stronger decreases of the precyclic baseline values from cycle 1 to 2 and from cycle 1 to 3. Thus, circulating nucleosomes are a valuable tool for the early prediction of therapeutic efficacy and can help to modulate therapy strategies early and on an individual basis.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1318.032