Immunological commonalities and distinctions between airway and digestive immunity

Airway and digestive tissues are the frontlines of the body’s defense, being continuously exposed to the outside environment and encountering large numbers of antigens and microorganisms. To achieve immunosurveillance and immunological homeostasis in the harsh environments of the mucosal surfaces, t...

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Bibliographic Details
Published in:Trends in immunology 2008-11, Vol.29 (11), p.505-513
Main Authors: Kunisawa, Jun, Nochi, Tomonori, Kiyono, Hiroshi
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibody Formation - immunology
Cell Movement - immunology
Cytokines
Digestive System - immunology
Digestive System - secretion
Humans
Immune system
Influenza
Lymphocytes
Lymphoid Tissue - cytology
Lymphoid Tissue - immunology
Mucous Membrane - immunology
Nitric oxide
Respiratory System - immunology
Rodents
Science
Studies
Technological change
Vaccines
Viruses
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Summary:Airway and digestive tissues are the frontlines of the body’s defense, being continuously exposed to the outside environment and encountering large numbers of antigens and microorganisms. To achieve immunosurveillance and immunological homeostasis in the harsh environments of the mucosal surfaces, the mucosal immune system tightly regulates a state of opposing but harmonized immune activation and quiescence. Recently, accumulating evidence has revealed that although the respiratory and intestinal immune systems share common mucosa-associated immunological features that are different from those of the systemic immune system, they also show distinctive immunological phenotypes, functions, and developmental pathways. We describe here the common and distinct immunological features of respiratory and intestinal immune systems and its application to the development of mucosal vaccines.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2008.07.008