Transplantation of a cadaveric polycystic kidney in a patient with autosomal dominant polycystic kidney disease: long-term outcome

Kidneys from donors affected by autosomal dominant polycystic kidney disease (ADPKD) were considered unusable for transplantation. To the best of our knowledge, seven cases worldwide have now been described in the English literature since 1967 suggesting such donor organs may be acceptable under cer...

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Bibliographic Details
Published in:Transplantation proceedings 2004-06, Vol.36 (5), p.1288-1292
Main Authors: Powell, C.R, Tata, S, Govani, M.V, Chien, G.W, Orvieto, M.A, Shalhav, A.L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy
Cadaver
Humans
Kidney Transplantation - pathology
Kidney Transplantation - physiology
Kidneys
Male
Malformations of the urinary system
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Polycystic Kidney Diseases - surgery
Polycystic Kidney, Autosomal Dominant - surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Time Factors
Tissue Donors
Treatment Outcome
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Summary:Kidneys from donors affected by autosomal dominant polycystic kidney disease (ADPKD) were considered unusable for transplantation. To the best of our knowledge, seven cases worldwide have now been described in the English literature since 1967 suggesting such donor organs may be acceptable under certain conditions. Most of these reports have only short-term follow-up. We provide a review of these patients and share our experience with an ADPKD patient who had a cadaveric ADPKD transplant and has been closely followed for 10 years. During the 10-year period, the patient had three transplant biopsies without complication. This creatinine is currently 1.2 mg/dL. Serial computed tomography imaging indicated that the cystic disease slowly progressed during this time period. He eventually developed intractable pain in his native left kidney and underwent a laparoscopic nephrectomy. Normal functioning cadaveric kidneys that show early signs of polycystic kidney disease should be considered acceptable for renal donation. These organs provide the recipient a safe, reasonable period of graft survival and have not been shown to cause adverse effects.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2004.05.003