Attenuated total reflection Fourier transform infrared and polarization spectroscopy of in vivo human skin ablated, layer by layer, by erbium:YAG laser

The results of an experimental study of the possibilities of monitoring erbium yttrium aluminum garnet laser-mediated ablation of human epidermis with the use of Fourier transform infrared (FTIR) spectroscopy and spectral polarization techniques are presented. The attenuated total reflection (ATR) m...

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Bibliographic Details
Published in:Journal of biomedical optics 2004-07, Vol.9 (4), p.820-827
Main Authors: Sviridov, Alexander P, Zimnyakov, Dmitry A, Sinichkin, Yury P, Butvina, Leonid N, Omelchenko, A J, Shakh, G S, Bagratashvili, Victor N
Format: Article
Language:English
Subjects:
Algorithms
Diagnosis, Computer-Assisted - methods
Feasibility Studies
Humans
Laser Therapy
Male
Microscopy, Polarization - methods
Middle Aged
Skin - radiation effects
Skin Diseases - diagnosis
Skin Diseases - surgery
Spectroscopy, Fourier Transform Infrared - methods
Treatment Outcome
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Summary:The results of an experimental study of the possibilities of monitoring erbium yttrium aluminum garnet laser-mediated ablation of human epidermis with the use of Fourier transform infrared (FTIR) spectroscopy and spectral polarization techniques are presented. The attenuated total reflection (ATR) method was used for FTIR spectroscopic measurements. Spectral polarization monitoring of the ablation was carried out by analyzing the spectra of the degree of residual linear polarization of a probe light diffusely reflected from the laser-treated region of skin. It was found that the analysis of FTIR spectra allows monitoring of the water and protein contents in the subsurface layers of the treated skin, while the degree of residual polarization measured at the wavelengths of maximal absorption of hemoglobin is sensitive to changes in the epidermis thickness and the blood content in the dermal layer (the degree of erythema).
ISSN:1083-3668
1560-2281
DOI:10.1117/1.1755719