Bactericidal/permeability-increasing protein (BPI) and BPI homologs at mucosal sites

At mucosal surfaces, we must co-exist with a high density of diverse microorganisms; therefore, protection against these occurs on multiple levels. Leukocyte- and epithelial derived–antimicrobial peptides and proteins (AMPs) comprise an essential component of immune defense. These molecules possess...

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Bibliographic Details
Published in:Trends in immunology 2008-11, Vol.29 (11), p.541-547
Main Authors: Canny, Geraldine, Levy, Ofer
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antimicrobial agents
Antimicrobial Cationic Peptides - chemistry
Antimicrobial Cationic Peptides - immunology
Antimicrobial Cationic Peptides - metabolism
Antimicrobial Cationic Peptides - therapeutic use
Bacteria
Blood Proteins - chemistry
Blood Proteins - immunology
Blood Proteins - metabolism
Blood Proteins - therapeutic use
Bone marrow
Crohn's disease
Crystal structure
Epithelial Cells - immunology
Epithelial Cells - metabolism
Gene expression
Gram-negative bacteria
Humans
Inflammation - immunology
Inflammation - metabolism
Lipids
Molecular weight
Mucous Membrane - chemistry
Mucous Membrane - immunology
Mucous Membrane - metabolism
Mucous Membrane - microbiology
Permeability
Phospholipids - immunology
Phospholipids - metabolism
Proteins
Rodents
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Summary:At mucosal surfaces, we must co-exist with a high density of diverse microorganisms; therefore, protection against these occurs on multiple levels. Leukocyte- and epithelial derived–antimicrobial peptides and proteins (AMPs) comprise an essential component of immune defense. These molecules possess antibacterial, antifungal and signalling properties and probably contribute to defence and maintenance of homeostasis between the host and commensal microorganisms. Among these AMPs is bactericidal/permeability-increasing protein (BPI), an antimicrobial protein with potent endotoxin-neutralising activity, and several homologs. This review explores the roles of BPI and and its homologs at the mucosal interface. Congeners of BPI are under biopharmaceutical development as novel anti-infective agents, highlighting the potential therapeutic relevance of this protein family.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2008.07.012