Bio-nanotechnology and photodynamic therapy—State of the art review

Summary Photodynamic therapy (PDT) and bio-nanotechnology (NT) show striking similarities in clinical design and mechanistics. The PDT paradigm of photosensitizer application, light activation and singlet oxygen generation does in fact occur on the nanoscale level as does the resultant outcomes. NT...

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Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2008-03, Vol.5 (1), p.19-28
Main Authors: Allison, R.R, Mota, H.C, Bagnato, V.S, Sibata, C.H., PhD
Format: Article
Language:English
Subjects:
Biotechnology
Hematology, Oncology and Palliative Medicine
Internal Medicine
Nanoparticles
Nanotechnology
Photochemotherapy
Photodiagnosis
Photodynamic therapy
Photosensitizing Agents - therapeutic use
Review
Review Literature as Topic
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Summary:Summary Photodynamic therapy (PDT) and bio-nanotechnology (NT) show striking similarities in clinical design and mechanistics. The PDT paradigm of photosensitizer application, light activation and singlet oxygen generation does in fact occur on the nanoscale level as does the resultant outcomes. NT has the ability to explain as well as modify each of the critical steps of PDT particularly photosensitizer design and delivery, light source miniaturization and optimization, location and intensity of the photodynamic reaction as well as offering a far greater insight into dosimetry and mechanisms of action. This review will explore the current and potential future interactions and modifications NT may have on PDT.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2008.02.001