Improvement of cognitive test performance in patients undergoing primary CABG and other CPB-assisted cardiac procedures

Cardiac surgical procedures assisted by cardiopulmonary bypass (CPB) impair cognitive functions. Several studies, however, showed that cognitive functions were unaffected in patients undergoing either primary coronary artery bypass grafting (CABG) or more complex surgery assisted by CPB. Therefore,...

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Bibliographic Details
Published in:Perfusion 2008-09, Vol.23 (5), p.267-273
Main Authors: van den Goor, JM, Saxby, BK, Tijssen, JG, Wesnes, KA, de Mol, BA, Nieuwland, R
Format: Article
Language:English
Subjects:
Cognition - physiology
Cognition Disorders - etiology
Coronary Artery Bypass - adverse effects
Coronary Artery Bypass - methods
Female
Humans
Male
Middle Aged
Neuropsychological Tests
Poa
Postoperative Period
Prospective Studies
Psychomotor Performance
Quality of Life
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Summary:Cardiac surgical procedures assisted by cardiopulmonary bypass (CPB) impair cognitive functions. Several studies, however, showed that cognitive functions were unaffected in patients undergoing either primary coronary artery bypass grafting (CABG) or more complex surgery assisted by CPB. Therefore, we conducted a straightforward study to compare patient groups who differed significantly in terms of risk factors such as prolonged CPB times. Consecutive patients (n = 54) were included, undergoing either non-primary CABG, e.g. valve and/or CABG, (n = 30) or primary CABG (n = 24), assisted by CPB. Cognitive function was determined pre-operatively on the day of hospital admission, and post-operatively after one and six months using the Cognitive Drug Research computerized assessment battery. Data from the fourteen individual task variables were summarized in four composite scores: Power of Attention (PoA), Continuity of Attention (CoA), Quality of Episodic Memory (QoEM), and Speed of Memory (SoM). In the non-primary CABG patients, both CoA and QoEM improved after 1 month (p = 0.001 and p = 0.016, respectively), whereas, after 6 months, CoA (p = 0.002), QoEM (p = 0.002) and SoM (p 
ISSN:0267-6591
1477-111X
DOI:10.1177/0267659109104561