The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids

The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids is reported. The presence of an N-chloroacetyl group as acyl group in the substrate as well as the use of porcine kidney acylase I as a suitable enzyme component are prerequisites for this resolution process whe...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2004-07, Vol.2 (14), p.1977-1978
Main Authors: Groger, Harald, Trauthwein, Harald, Buchholz, Stefan, Drauz, Karlheinz, Sacherer, Christiane, Godfrin, Sylvie, Werner, Helge
Format: Article
Language:English
Subjects:
Amidohydrolases - chemistry
Amino Acids - chemical synthesis
Catalysis
Molecular Conformation
Molecular Structure
Stereoisomerism
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Summary:The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids is reported. The presence of an N-chloroacetyl group as acyl group in the substrate as well as the use of porcine kidney acylase I as a suitable enzyme component are prerequisites for this resolution process whereby optically active beta-amino acids are formed with high enantioselectivities of >98% ee.
ISSN:1477-0520
1477-0539
DOI:10.1039/b406380e