Association of the thyroglobulin gene polymorphism with autoimmune thyroid disease in Chinese population

Objective This study was performed to identify the presence of previously reported thyroglobulin (Tg) gene single nucleotide polymorphisms (SNPs) in Han Chinese Asians, and to investigate their potential relation to autoimmune thyroid disease (AITD). Methods Polymorphisms were determined by polymera...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine 2008-06, Vol.33 (3), p.294-299
Main Authors: Maierhaba, Mai, Zhang, Jin-an, Yu, Zhi-yun, Wang, Yu, Xiao, Wan-xia, Quan, Ying, Dong, Bao-ning
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group - genetics
Asian Continental Ancestry Group - statistics & numerical data
Case-Control Studies
Diabetes
Endocrinology
Female
Gene Frequency
Genetic Predisposition to Disease - ethnology
Graves Disease - ethnology
Graves Disease - genetics
Haplotypes
Hashimoto Disease - ethnology
Hashimoto Disease - genetics
Humanities and Social Sciences
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
multidisciplinary
Original Paper
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Science
Thyroglobulin - genetics
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective This study was performed to identify the presence of previously reported thyroglobulin (Tg) gene single nucleotide polymorphisms (SNPs) in Han Chinese Asians, and to investigate their potential relation to autoimmune thyroid disease (AITD). Methods Polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) in 228 Chinese patients with AITD (146 with Graves’ disease and 82 with Hashimoto’s thyroiditis) and 131 healthy Chinese controls. Results (1) The occurrence of four common Tg gene SNPs (E10SNP24 T/G and E10SNP158 T/C in exon 10, E12SNP A/G in exon 12, and E33SNP C/T in exon 33) was confirmed in this Chinese population. No differences in allele and genotype frequencies were found between AITD patients and control subjects, or between male and female individuals in any group. Neither were differences in allele frequencies observed when Graves’ disease (GD) or Hashimoto’s thyroiditis (HT) patients were analyzed separately. (2) Haplotype analysis of these four SNPs revealed that the G-C-A-C haplotype was significantly associated with HT ( P  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-008-9082-x