Serum pepsinogens as a predicator of the topography of intestinal metaplasia in patients with atrophic gastritis

The importance of atrophic gastritis with intestinal metaplasia is related to the fact that it increases the risk of gastric cancer development. The aim of this study is to evaluate the diagnostic potential of serum pepsinogens in predicting the topography of intestinal metaplasia. Both dye endoscop...

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Bibliographic Details
Published in:Digestive diseases and sciences 2004-05, Vol.49 (5), p.795-801
Main Authors: URITA, Yoshihisa, HIKE, Kazuo, TORII, Naotaka, KIKUCHI, Yoshinori, KANDA, Eiko, SASAJIMA, Masahiko, MIKI, Kazumasa
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastric Mucosa - pathology
Gastritis, Atrophic - blood
Gastritis, Atrophic - diagnosis
Gastritis, Atrophic - pathology
Gastroenterology. Liver. Pancreas. Abdomen
Gastroscopy
Helicobacter pylori
Human bacterial diseases
Humans
Infectious diseases
Male
Mass Screening
Medical sciences
Metabolic diseases
Metaplasia - blood
Metaplasia - diagnosis
Middle Aged
Other diseases. Semiology
Pepsinogens - blood
Predictive Value of Tests
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:The importance of atrophic gastritis with intestinal metaplasia is related to the fact that it increases the risk of gastric cancer development. The aim of this study is to evaluate the diagnostic potential of serum pepsinogens in predicting the topography of intestinal metaplasia. Both dye endoscopy and 13C-urea breath test were carried out in 878 subjects. Serum pepsinogen I, pepsinogen II, and IgG antibody to Helicobacter pylori were measured. The overall prevalence of intestinal metaplasia was higher in subjects with lower PG I/II ratios and lower PG I values. Based on ROC curves, a cutoff value for pepsinogen I/II ratio of less than 3.0 would have identified intestinal metaplasia with a sensitivity of 71.7% and a specificity of 66.7% in Helicobacter pylori-positive subjects. It is possible that serum pepsinogens could be used as a screening test for high-risk subjects with intestinal metaplasia.
ISSN:0163-2116
1573-2568
DOI:10.1023/B:DDAS.0000030091.92379.91