Bilberry inhibits angiogenesis in chick chorioallontoic membrane

Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. Bilberry has been traditionally used as a folk medicine for some countries. The purpose of the present study was to evaluate the effect of bilberry in chi...

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Bibliographic Details
Published in:BioFactors (Oxford) 2008, Vol.33 (3), p.161-164
Main Authors: Ozgurtas, Taner, Aydin, Ibrahim, Tapan, Serkan, Avci, Ozgur, Erbil, M. Kemal
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenesis Inhibitors - pharmacology
Angiogenesis Inhibitors - therapeutic use
Animals
Anthocyanins - pharmacology
Anthocyanins - therapeutic use
anti-angiogenesis
bilberry
Chick Embryo
Chorioallantoic Membrane - drug effects
Neovascularization, Pathologic - drug therapy
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Vaccinium myrtillus
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Summary:Angiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. Bilberry has been traditionally used as a folk medicine for some countries. The purpose of the present study was to evaluate the effect of bilberry in chick chorioallantoic membrane angiogenesis model in vivo. In this well characterized model, bilberry inhibited angiogenesis in a concentration‐dependent manner. Compared with the normal group, bilberry group has significant decreased vessels proliferation. These results provide evidence that bilberry inhibits angiogenesis and may be useful for treating angiogenesis‐dependent human diseases.
ISSN:0951-6433
1872-8081
DOI:10.1002/biof.5520330301