Comparison of fentanyl versus meperidine for analgesia in pediatric gastrointestinal endoscopy

This study compared the safety and efficacy of fentanyl and meperidine for analgesia in pediatric gastrointestinal endoscopy. In a double-blind, randomized trial, 24 patients (11 males) received either fentanyl (1 microg/kg) or meperidine (1 mg/kg). These analgesics were administered in unmarked syr...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 2004-05, Vol.49 (5), p.888-891
Main Authors: ALI, Sabina, DAVIDSON, D. Lyn, GREMSE, David A
Format: Article
Language:English
Subjects:
Adolescent
Analgesics, Opioid
Biological and medical sciences
Child
Child, Preschool
Double-Blind Method
Endoscopy, Digestive System
Feeding. Feeding behavior
Female
Fentanyl
Fundamental and applied biological sciences. Psychology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hypnotics and Sedatives
Male
Medical sciences
Meperidine
Metabolic diseases
Midazolam
Treatment Outcome
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study compared the safety and efficacy of fentanyl and meperidine for analgesia in pediatric gastrointestinal endoscopy. In a double-blind, randomized trial, 24 patients (11 males) received either fentanyl (1 microg/kg) or meperidine (1 mg/kg). These analgesics were administered in unmarked syringes by an investigator who did not participate in the procedure or in the evaluation of the patient's sedation. There were 17 Caucasians and 7 African-Americans whose mean age was 10.4 +/- 4.4 years. Thirteen patients received meperidine and 11 received fentanyl. Midazolam was given to all patients as needed to provide sufficient sedation for the procedure. Study subjects underwent EGD (n = 17) or colonoscopy (n = 7). There were no differences as assessed by patient, endoscopist, or assistant for tolerance, discomfort, procedure ease, recovery time, complications, heart rate, blood pressure, or oxygen saturation. We conclude that meperidine and fentanyl are equally effective in providing analgesia for pediatric gastrointestinal endoscopy.
ISSN:0163-2116
1573-2568
DOI:10.1023/B:DDAS.0000030106.01928.b4