Permanent Modification of Neurohormone Expression in the Hypothalamus of Rats on the Model of Learned Helplessness

Depressive state of Wistar rats in the model of learned helplessness was accompanied by a persistent increase in the expression of corticotropin-releasing factor in the hypothalamus. Vasopressin content in the hypothalamus was modified only in the early poststress period and remained unchanged at th...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-10, Vol.146 (4), p.388-390
Main Authors: Mironova, V. I, Rybnikova, E. A
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
corticotropin-releasing hormone
Corticotropin-Releasing Hormone - metabolism
depression
Helplessness, Learned
hypothalamus
Hypothalamus - metabolism
Immunohistochemistry
Internal Medicine
Laboratory Medicine
learned helplessness
Male
Pathology
Physiology
Rats
Rats, Wistar
vasopressin
Vasopressins - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Depressive state of Wistar rats in the model of learned helplessness was accompanied by a persistent increase in the expression of corticotropin-releasing factor in the hypothalamus. Vasopressin content in the hypothalamus was modified only in the early poststress period and remained unchanged at the late stage of experimental depression. Our results indicate that hypothalamic corticotropin-releasing factor (but not vasopressin) plays an important role in the development of experimental mental disorders.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0314-8