Sensitivity of Adrenal Glands to Adrenocorticotropic Hormone in Animals with Alimentary Obesity

Blood concentration of corticosterone in obese rats did not differ from the control value. In vitro synthesis of progesterone and corticosterone in adrenal slices from obese rats was lower compared to control animals, but these differences disappeared after addition of adrenocorticotropic hormone to...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-12, Vol.146 (6), p.711-713
Main Authors: Pankina, T. V, Kuzminova, O. I, Selyatitskaya, V. G
Format: Article
Language:English
Subjects:
adrenal cortex hormones
Adrenal Cortex Hormones - blood
Adrenal Cortex Hormones - metabolism
adrenal glands
Adrenal Glands - drug effects
Adrenal Glands - metabolism
Adrenocorticotropic Hormone - pharmacology
alimentary obesity
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
corticotropin
General Pathology and Pathophysiology
Hormones - pharmacology
In Vitro Techniques
Internal Medicine
Laboratory Medicine
Male
Obesity - metabolism
Pathology
Rats
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Summary:Blood concentration of corticosterone in obese rats did not differ from the control value. In vitro synthesis of progesterone and corticosterone in adrenal slices from obese rats was lower compared to control animals, but these differences disappeared after addition of adrenocorticotropic hormone to the incubation medium. In obese rats, blood content of corticosterone in response to administration of adrenocorticotropic hormone in vivo increased by 8 times, while in control animals this parameter increased by only 4.5 times.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0394-5