Morphological Study of the Efficiency of Isoniazid and Dialdehyde Dextran Composition in the Treatment of Mice with BCG Granulomatosis

Male BALB/c mice were intraperitoneally injected with BCG vaccine. After 1 month therapy was started: isoniazid or composition of isoniazid with dialdehyde dextran (CID) obtained by chemical and radiochemical methods. The therapeutic efficiency evaluated by the number granulomas in the liver and lun...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-12, Vol.146 (6), p.853-856
Main Authors: Shkurupiy, V. A, Kozyaev, M. A, Potapova, O. V
Format: Article
Language:English
Subjects:
Animals
Antitubercular Agents - therapeutic use
BCG granulomatosis
BCG Vaccine - adverse effects
Biomedical and Life Sciences
Biomedicine
Cell Biology
Dextrans - therapeutic use
dialdehyde dextran
Granuloma - drug therapy
Granuloma - etiology
hepatotoxicity
Internal Medicine
isoniazid
Isoniazid - therapeutic use
Laboratory Medicine
liver
Liver - pathology
Lung - pathology
lungs
Male
Mice
Mice, Inbred BALB C
Morphology and Pathomorphology
Pathology
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Summary:Male BALB/c mice were intraperitoneally injected with BCG vaccine. After 1 month therapy was started: isoniazid or composition of isoniazid with dialdehyde dextran (CID) obtained by chemical and radiochemical methods. The therapeutic efficiency evaluated by the number granulomas in the liver and lungs and granuloma size was higher in mice treated with CID obtained by the radiochemical method in comparison with mice treated with isoniazid and with CID obtained by the chemical method. Hepatotoxicity evaluated by volume density of degenerative hepatocytes and necrotic zones was higher in mice treated with CID obtained by the radiochemical method than in animals treated with isoniazid, because CID contained free isoniazid and isoniazid bound to dialdehyde dextran.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0401-x