Induction of Interferon Production by Conformation-Modified Proteins of Plasma γ-Globulin Fraction

Plasma γ-globulin fraction proteins, copper and zinc cations, and metal-modified γ-globulins induce the production of IFN by human leukocytes. Binding of zinc cations attenuates the realization of the IFN-inducing effects of human serum γ-globulin, while binding of copper cations potentiated this ef...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-11, Vol.146 (5), p.591-595
Main Authors: Cheknyov, S. B, Babayants, A. A, Denisova, E. A
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cells, Cultured
conformation
Copper - metabolism
gamma-Globulins - chemistry
gamma-Globulins - metabolism
gamma-Globulins - pharmacology
Gene Expression Regulation - drug effects
Humans
induction
Interferon-gamma - metabolism
interferons
Interferons - metabolism
Internal Medicine
Laboratory Medicine
Leukocytes - drug effects
Leukocytes - metabolism
Microbiology and Immunology
Pathology
Protein Binding
Protein Conformation
Zinc - metabolism
γ-globulin
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Summary:Plasma γ-globulin fraction proteins, copper and zinc cations, and metal-modified γ-globulins induce the production of IFN by human leukocytes. Binding of zinc cations attenuates the realization of the IFN-inducing effects of human serum γ-globulin, while binding of copper cations potentiated this effect. Activity of IFN and the dynamics of its production correspond to those in response to phytohemagglutinin stimulation. The pool of induced IFN contains acid-labile (up to 60%) and acid-stable (up to 40%) constituents. Anti-IFN-α antibodies do not modify activity of produced IFN. The results indicate the possibility of γ-globulin conformation allowing stimulation or attenuation of the protein capacity to induce the production of IFN pool with predominant content of IFN-γ.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0349-x