Potentialities of Differential Immunohistochemical Diagnosis of Some Follicular Tumors of the Thyroid Gland

Differential diagnosis of thyroid follicular adenomas, follicular cancer, and papillary cancer with follicular structure was carried out. Proliferation coefficients, probability of atypia, and tumor growth activity were evaluated on the basis of quantitative proportions of proliferation and apoptosi...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-12, Vol.146 (6), p.794-796
Main Authors: Poloz, T. L, Shkurupiy, V. A
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
follicular tumors
Humans
immunohistochemistry
Immunohistochemistry - methods
Internal Medicine
Ki-67 Antigen - metabolism
Laboratory Medicine
Oncology
Pathology
Proto-Oncogene Proteins c-bcl-2 - metabolism
thyroid
Thyroid Gland - metabolism
Thyroid Gland - pathology
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - metabolism
Tumor Suppressor Protein p53 - metabolism
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Summary:Differential diagnosis of thyroid follicular adenomas, follicular cancer, and papillary cancer with follicular structure was carried out. Proliferation coefficients, probability of atypia, and tumor growth activity were evaluated on the basis of quantitative proportions of proliferation and apoptosis genes expression, derived from indexes of labeled nuclei expressing Ki-67, bcl2, p53 and cytoplasm with expression of bcl2, p53 in cells of these tumors. Significant differences between all the studied tumors of the thyroid grand with follicular structure were detected. The proposed criteria supplement the postoperative morphological differential diagnosis of thyroid tumors.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0419-0