Backbone assignment of osteopontin, a cytokine and cell attachment protein implicated in tumorigenesis

OPN is an RGD-containing protein overexpressed in cells transformed by v-myc and v-mil ( raf ) oncogenes. Here we report the resonance assignment of recombinant quail OPN and provide NMR evidence that quail OPN is an intrinsically unstructured protein in solution.

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Bibliographic Details
Published in:Biomolecular NMR assignments 2008-06, Vol.2 (1), p.29-31
Main Authors: Schedlbauer, Andreas, Ozdowy, Przemyslaw, Kontaxis, Georg, Hartl, Markus, Bister, Klaus, Konrat, Robert
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biochemistry
Biological and Medical Physics
Biophysics
Carbon Isotopes - chemistry
Cell Adhesion Molecules - chemistry
Cellular biology
Cytokines
Cytokines - chemistry
Genetics
Magnetic Resonance Spectroscopy - methods
Molecular Sequence Data
Molecular Weight
Neoplasms - metabolism
Nitrogen Isotopes - chemistry
Osteopontin - chemistry
Physics
Physics and Astronomy
Polymer Sciences
Proteins
Protons
Quail - metabolism
Tumors
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Description
Summary:OPN is an RGD-containing protein overexpressed in cells transformed by v-myc and v-mil ( raf ) oncogenes. Here we report the resonance assignment of recombinant quail OPN and provide NMR evidence that quail OPN is an intrinsically unstructured protein in solution.
ISSN:1874-2718
1874-270X
DOI:10.1007/s12104-007-9076-2