Surgical treatment of stage IV melanoma

Surgical therapy plays an important role in the management of selected patients with metastatic melanoma. Patients are frequently symptomatic from metastatic lesions, have few effective therapeutic options, and are faced with dismal outcomes. Surgical resection may provide successful palliation of s...

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Bibliographic Details
Published in:Clinics in dermatology 2004-05, Vol.22 (3), p.240-250
Main Authors: Spanknebel, Kathryn, Kaufman, Howard L.
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - secondary
Adrenal Gland Neoplasms - surgery
Brain Neoplasms - secondary
Brain Neoplasms - surgery
Gastrointestinal Neoplasms - secondary
Gastrointestinal Neoplasms - surgery
Humans
Liver Neoplasms - secondary
Liver Neoplasms - surgery
Lung Neoplasms - secondary
Lung Neoplasms - surgery
Melanoma - secondary
Melanoma - surgery
Neoplasm Staging
Prognosis
Survival Analysis
Time Factors
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Summary:Surgical therapy plays an important role in the management of selected patients with metastatic melanoma. Patients are frequently symptomatic from metastatic lesions, have few effective therapeutic options, and are faced with dismal outcomes. Surgical resection may provide successful palliation of symptomatic lesions with low morbidity and operative mortality. In carefully selected patients, resections performed with curative intent may result in improved survival if a pattern of disease recurrence suggestive of favorable tumor biology is present, and if complete resection of tumor is achieved. Because the majority of post-surgical metastatic patients eventually relapse and succumb to distant disease, adjuvant immunotherapeutic strategies are currently being evaluated.
ISSN:0738-081X
1879-1131
DOI:10.1016/j.clindermatol.2003.12.004