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Predicting protein folding pathways
A structured folding pathway, which is a time ordered sequence of folding events, plays an important role in the protein folding process and hence, in the conformational search. Pathway prediction, thus gives more insight into the folding process and is a valuable guiding tool to search the conforma...
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| Published in: | Bioinformatics 2004-08, Vol.20 (suppl-1), p.i386-i393 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c516t-610a5caaaa1e9f4ae11f3895745f0521fb10d6cde9411057eea29927fa2ce50f3 |
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| container_end_page | i393 |
| container_issue | suppl-1 |
| container_start_page | i386 |
| container_title | Bioinformatics |
| container_volume | 20 |
| creator | Zaki, Mohammed J. Nadimpally, Vinay Bardhan, Deb Bystroff, Chris |
| description | A structured folding pathway, which is a time ordered sequence of folding events, plays an important role in the protein folding process and hence, in the conformational search. Pathway prediction, thus gives more insight into the folding process and is a valuable guiding tool to search the conformation space. In this paper, we propose a novel ‘unfolding’ approach to predict the folding pathway. We apply graph-based methods on a weighted secondary structure graph of a protein to predict the sequence of unfolding events. When viewed in reverse this yields the folding pathway. We demonstrate the success of our approach on several proteins whose pathway is partially known. |
| doi_str_mv | 10.1093/bioinformatics/bth935 |
| format | article |
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| identifier | ISSN: 1367-4803 |
| ispartof | Bioinformatics, 2004-08, Vol.20 (suppl-1), p.i386-i393 |
| issn | 1367-4803 1460-2059 1367-4811 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66721915 |
| source | Oxford Journals Open Access Collection |
| subjects | Amino Acid Sequence Computer Simulation Models, Chemical Models, Molecular Molecular Conformation Protein Conformation Protein Folding Proteins - chemistry Proteins - ultrastructure Sequence Analysis, Protein - methods |
| title | Predicting protein folding pathways |
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