Dictyostelium morphogenesis

During starvation-induced Dictyostelium development, up to several hundred thousand amoeboid cells aggregate, differentiate and form a fruiting body. The chemotactic movement of the cells is guided by the rising phase of the outward propagating cAMP waves and results in directed periodic movement to...

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Bibliographic Details
Published in:Current opinion in genetics & development 2004-08, Vol.14 (4), p.392-398
Main Author: Weijer, Cornelis J
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion - physiology
Cell Differentiation - physiology
Cell Movement - physiology
Cyclic AMP - metabolism
Cyclic AMP - physiology
Dictyostelium
Dictyostelium - physiology
Gene Expression Regulation
Morphogenesis
Signal Transduction - physiology
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Summary:During starvation-induced Dictyostelium development, up to several hundred thousand amoeboid cells aggregate, differentiate and form a fruiting body. The chemotactic movement of the cells is guided by the rising phase of the outward propagating cAMP waves and results in directed periodic movement towards the aggregation centre. In the mound and slug stages of development, cAMP waves continue to play a major role in the coordination of cell movement, cell-type-specific gene expression and morphogenesis; however, in these stages where cells are tightly packed, cell–cell adhesion/contact-dependent signalling mechanisms also play important roles in these processes.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2004.06.006