Metastatic insular thyroid carcinoma in the pediatric patient

Abstract Objectives The clinical history of a pediatric patient with metastatic insular thyroid carcinoma will be reviewed. Previously reported cases will be examined to allow for comparison of prognosis. Methods A 4-year-old female with the complaint of chronic cough, progressive shortness of breat...

Full description

Saved in:
Bibliographic Details
Published in:American journal of otolaryngology 2009, Vol.30 (1), p.61-64
Main Authors: Donnellan, Kimberly A., MD, Carron, Jeffery D., MD, Bigler, Steven A., MD, Wein, Richard O., MD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy, Needle
Carcinoma, Papillary, Follicular - pathology
Carcinoma, Papillary, Follicular - secondary
Carcinoma, Papillary, Follicular - surgery
Child, Preschool
Dissection
Endocrinopathies
Family medical history
Female
Follow-Up Studies
Humans
Immunohistochemistry
Iodine Radioisotopes - therapeutic use
Lung Neoplasms - pathology
Lung Neoplasms - secondary
Lungs
Lymph Node Excision - methods
Lymph Nodes - pathology
Lymphatic Metastasis
Malignant tumors
Medical sciences
Mortality
Neck Dissection
Neoplasm Invasiveness - pathology
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Ostomy
Otolaryngology
Otorhinolaryngology. Stomatology
Postoperative Care
Risk Assessment
Surgery
Thyroid cancer
Thyroid gland
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroid. Thyroid axis (diseases)
Thyroidectomy - methods
Treatment Outcome
Tuberculosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objectives The clinical history of a pediatric patient with metastatic insular thyroid carcinoma will be reviewed. Previously reported cases will be examined to allow for comparison of prognosis. Methods A 4-year-old female with the complaint of chronic cough, progressive shortness of breath, and weight loss for 2 months underwent cervical lymph node biopsy. The biopsy revealed metastatic thyroid carcinoma. Preoperative imaging was suspicious for miliary metastatic spread to the lungs. Results Surgical intervention included total thyroidectomy with bilateral paratracheal and modified radical neck dissections. The right internal jugular vein and recurrent laryngeal nerve were removed at the time of surgery because of gross tumor invasion. Final pathologic finding revealed papillary thyroid carcinoma with insular variant features and bilateral regional metastasis. Postoperatively, the patient underwent radioactive iodine I 131 treatment. Conclusion Pediatric metastatic insular thyroid carcinoma is an uncommon form of thyroid malignancy requiring aggressive surgical treatment and adjuvant radioactive iodine.
ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2008.01.002