Growth responses of Cassia obtusifolia toward human intestinal bacteria

1,2-Dihydroxyanthraquinone ( 1) was isolated from the seed of Cassia obtusifolia through bioassay-guided fractionation. 1,2-Dihydroxyanthraquinone strongly inhibited the growth of Clostridium perfringens and Escherichia coli. Structure-activity relationship revealed that 1,4-dihydroxyanthraquinone (...

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Bibliographic Details
Published in:Fitoterapia 2004-07, Vol.75 (5), p.505-509
Main Authors: Sung, Bo-Kyung, Kim, Moo-Key, Lee, Wang-Hyu, Lee, Dong-Heon, Lee, Hoi-Seon
Format: Article
Language:English
Subjects:
1,2-Dihydroxyanthraquinone
Anthraquinones
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Bifidobacterium bifidum
Biological and medical sciences
Cassia
Cassia obtusifolia
Clostridium perfringens
Clostridium perfringens - drug effects
Escherichia coli
Escherichia coli - drug effects
General pharmacology
Growth response
Humans
Intestinal bacteria
Medical sciences
Microbial Sensitivity Tests
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
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Summary:1,2-Dihydroxyanthraquinone ( 1) was isolated from the seed of Cassia obtusifolia through bioassay-guided fractionation. 1,2-Dihydroxyanthraquinone strongly inhibited the growth of Clostridium perfringens and Escherichia coli. Structure-activity relationship revealed that 1,4-dihydroxyanthraquinone ( 2) and 1,8-dihydroxyanthraquinone ( 3) had strong growth-inhibition against C. perfringens. In growth-promoting activity, 1,2-, 1,4-, and 1,8-dihydroxyanthraquinones exhibited strong growth-promoting activity to Bifidobacterium bifidum.
ISSN:0367-326X
DOI:10.1016/j.fitote.2004.03.012