Photodynamic therapy of brain tumours: evaluation of porphyrin uptake versus clinical outcome

The objective of this study was to investigate whether the level of the photosensitizer haematoporphyrin derivative (HpD) uptake measured in tissue samples taken from brain tumour patients was associated with survival post-treatment with photodynamic therapy (PDT). The mean HpD uptake in tumour tiss...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2004-08, Vol.11 (6), p.584-596
Main Authors: Stylli, Stanley S., Howes, Megan, MacGregor, Lachlan, Rajendra, Priya, Kaye, Andrew H.
Format: Article
Language:English
Subjects:
Adult
Astrocytoma - blood
Astrocytoma - drug therapy
Astrocytoma - metabolism
Astrocytoma - mortality
Brain Neoplasms - blood
Brain Neoplasms - drug therapy
Brain Neoplasms - metabolism
Brain Neoplasms - mortality
brain tumours
Chi-Square Distribution
Dose-Response Relationship, Drug
Evaluation Studies as Topic
Female
Follow-Up Studies
Glioblastoma - blood
Glioblastoma - drug therapy
Glioblastoma - metabolism
Glioblastoma - mortality
Hematoporphyrin Derivative
Hematoporphyrins - pharmacokinetics
Humans
Lipoproteins - blood
Male
Middle Aged
Photochemotherapy - methods
photodynamic therapy
Photosensitizing Agents - pharmacokinetics
porphyrin
Survival Analysis
Time Factors
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Summary:The objective of this study was to investigate whether the level of the photosensitizer haematoporphyrin derivative (HpD) uptake measured in tissue samples taken from brain tumour patients was associated with survival post-treatment with photodynamic therapy (PDT). The mean HpD uptake in tumour tissue was significantly higher in glioblastoma multiforme than anaplastic astrocytoma. Recurrent tumours had a higher mean uptake compared to primary tumours, which was evident in all grades of tumour. Among patients with GBM, there was a significant association between greater HpD uptake and survival ( HR = 0.26   [ 0.12 , 0.59 ] , p=0.001). There was also some evidence of a weak association between greater HpD uptake and survival among patients with AA, although the result was inconclusive ( HR = 0.73   [ 0.32 , 1.71 ] , p=0.472).
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2004.02.001