Complete protection of sodium valproate from humidity by using a hydrotalcite composite

Complete protection of sodium valproate from humidity was successfully accomplished by intercalation into a hydrotalcite-like compound. The obtained hybrid of sodium valproate and the hydrotalcite-like compound was stable and not at all hygroscopic. Even under a relative humidity of 97%, the adsorbe...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2009-01, Vol.98 (1), p.46-49
Main Authors: Nakayama, Hirokazu, Akasaka, Hiroko, Tsuhako, Mitsutomo
Format: Article
Language:English
Subjects:
Aluminum Hydroxide - chemistry
Biological and medical sciences
Chemistry, Pharmaceutical - methods
Drug Stability
Drug Storage - methods
General pharmacology
Humidity - prevention & control
hydrotalcite
hygroscopicity
Magnesium Hydroxide - chemistry
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
polymorphism
sodium valproate
Valproic Acid - chemistry
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Summary:Complete protection of sodium valproate from humidity was successfully accomplished by intercalation into a hydrotalcite-like compound. The obtained hybrid of sodium valproate and the hydrotalcite-like compound was stable and not at all hygroscopic. Even under a relative humidity of 97%, the adsorbed amount of water was less than 0.5%.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.21414