Synthesis and DNA binding affinity of novel A- C8/ C- C2- exo unsaturated alkoxyamido-linked pyrrolo[2,1- c][1,4]benzodiazepine dimers

Graphic The synthesis of novel A- C8/ C- C2- exo unsaturated alkoxyamido-linked pyrrolo[2,1- c][1,4]benzodiazepine dimers is reported and these dimers show significant DNA binding affinity and they also exhibit moderate anticancer activity.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2004-08, Vol.12 (16), p.4337-4350
Main Authors: Kamal, Ahmed, Srinivas, O, Ramulu, P, Ramesh, G, Kumar, P.Praveen, Kumar, M.Shiva
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Benzodiazepines - chemical synthesis
Benzodiazepines - metabolism
Benzodiazepines - pharmacology
Biological and medical sciences
Cell Line, Tumor
Cross-Linking Reagents - chemical synthesis
Cross-Linking Reagents - pharmacology
Cytotoxicity
Dimerization
DNA - metabolism
DNA binding affinity
General aspects
Humans
Medical sciences
Pharmacology. Drug treatments
Pyrroles - chemical synthesis
Pyrroles - metabolism
Pyrroles - pharmacology
Pyrrolobenzodiazepine dimers
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Summary:Graphic The synthesis of novel A- C8/ C- C2- exo unsaturated alkoxyamido-linked pyrrolo[2,1- c][1,4]benzodiazepine dimers is reported and these dimers show significant DNA binding affinity and they also exhibit moderate anticancer activity.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2004.06.013