Osteomyelitis and Arthritis

Infections of bone and the joints can represent major diagnostic and therapeutic challenges to all clinicians. Together with osteomyelitis and septic arthritis, soft-tissue infections like cellulites/fasciitis and abscess formation can occur, which have to be treated appropriately. Bone scintigraphy...

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Bibliographic Details
Published in:Seminars in nuclear medicine 2009, Vol.39 (1), p.27-35
Main Authors: Stumpe, Katrin D.M., MD, Strobel, Klaus, MD
Format: Article
Language:English
Subjects:
Antibodies
Arthritis, Infectious - diagnosis
Arthritis, Infectious - diagnostic imaging
Humans
Indium Radioisotopes
Leukocytes - cytology
Leukocytes - diagnostic imaging
Magnetic Resonance Imaging
Musculoskeletal System - diagnostic imaging
Musculoskeletal System - immunology
Organotechnetium Compounds
Osteomyelitis - diagnosis
Osteomyelitis - diagnostic imaging
Radiology
Radionuclide Imaging
Tomography, X-Ray Computed
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Summary:Infections of bone and the joints can represent major diagnostic and therapeutic challenges to all clinicians. Together with osteomyelitis and septic arthritis, soft-tissue infections like cellulites/fasciitis and abscess formation can occur, which have to be treated appropriately. Bone scintigraphy is a sensitive method that can be used to search for bone and joint infections. Labeled leukocytes often are used as the gold standard to identify infectious foci in the musculoskeletal system, but major drawbacks of this method are the imaging of chronic infections and imaging of the axial skeleton. Like111 In-labeled leukocyte imaging,99m Tc-labeled antigranulocyte antibody scintigraphy has a role in the imaging of osteomyelitis of the peripheral skeleton. Magnetic resonance imaging is widely used to evaluate musculoskeletal infections and is excellent in identifying abscess formation, but the extent and spread of infection is sometimes difficult to delineate because hyperemia and infection are not congruent.
ISSN:0001-2998
1558-4623
DOI:10.1053/j.semnuclmed.2008.08.003