Evidence of octacalcium phosphate and Type-B carbonated apatites deposited on the surface of explanted acrylic hydrogel intraocular lens

Fourier‐transform infrared (FTIR) microspectroscopy combining with attenuated total reflection (ATR) microsampling technique and micro‐Raman spectrophotometer were used to detect the deposited materials on the surface of acrylic hydrogel intraocular lens (IOL) with or without ocular implantation. Su...

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Bibliographic Details
Published in:Journal of biomedical materials research 2004-08, Vol.70B (2), p.203-208
Main Authors: Lin, Shan-Yang, Chen, Ko-Hua, Li, May-Jane, Cheng, Wen-Ting, Wang, Shun-Li
Format: Article
Language:English
Subjects:
acrylic hydrogel IOL
Aged
Apatites - chemistry
Calcium Phosphates - chemistry
FTIR/Raman microspectroscopy
Humans
Hydrogels
Lenses, Intraocular
Male
Microscopy, Confocal
octacalcium phosphate
opacification
Spectroscopy, Fourier Transform Infrared
Spectrum Analysis, Raman
Type B carbonated apatites
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Summary:Fourier‐transform infrared (FTIR) microspectroscopy combining with attenuated total reflection (ATR) microsampling technique and micro‐Raman spectrophotometer were used to detect the deposited materials on the surface of acrylic hydrogel intraocular lens (IOL) with or without ocular implantation. Surface morphology and the interface of this IOL were further examined by a confocal laser scanning microscope. The brand‐new IOL exhibited a very smooth, transparent and featureless surface, but the explanted IOL had an irregular cerebriform‐like opaque appearance. Both FTIR/ATR and Raman microspectroscopic analyses showed the deposits on the surface of acrylic hydrogel IOL after ocular implantation to consist of octacalcium phosphate (OCP) and Type B carbonated apatites, leading to the opalescence of acrylic hydrogel IOL. Both vibrational microspectroscopic examinations also confirmed the mineralization still in progress on the surface of acrylic hydrogel IOL after ocular implantation for 2 years. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 70B: 203–208, 2004
ISSN:1552-4973
0021-9304
1552-4981
DOI:10.1002/jbm.b.30067