Advances in understanding and treatment of immune-mediated disorders of the peripheral nervous system

During recent years, novel insights in basic immunology and advances in biotechnology have contributed to an increased understanding of the pathogenetic mechanisms of immune‐mediated disorders of the peripheral nervous system. This increased knowledge has an impact on the management of patients with...

Full description

Saved in:
Bibliographic Details
Published in:Muscle & nerve 2004-08, Vol.30 (2), p.131-156
Main Authors: Kieseier, Bernd C., Kiefer, Reinhard, Gold, Ralf, Hemmer, Bernhard, Willison, Hugh J., Hartung, Hans-Peter
Format: Article
Language:English
Subjects:
Animals
autoimmunity
Biological and medical sciences
chronic inflammatory demyelinating polyneuropathy
experimental autoimmune neuritis
Guillain-Barre Syndrome - diagnosis
Guillain-Barre Syndrome - etiology
Guillain-Barre Syndrome - immunology
Guillain-Barre Syndrome - therapy
Guillain-Barré syndrome
Humans
Immune System Diseases - complications
Infection - complications
Medical sciences
multifocal motor neuropathy
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Neurology - trends
peripheral nervous system
Peripheral Nervous System Diseases - diagnosis
Peripheral Nervous System Diseases - etiology
Peripheral Nervous System Diseases - immunology
Peripheral Nervous System Diseases - therapy
vasculitis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:During recent years, novel insights in basic immunology and advances in biotechnology have contributed to an increased understanding of the pathogenetic mechanisms of immune‐mediated disorders of the peripheral nervous system. This increased knowledge has an impact on the management of patients with this class of disorders. Current advances are outlined and their implication for therapeutic approaches addressed. As a prototypic immune‐mediated neuropathy, special emphasis is placed on the pathogenesis and treatment of the Guillain–Barré syndrome and its variants. Moreover, neuropathies of the chronic inflammatory demyelinating, multifocal motor, and nonsystemic vasculitic types are discussed. This review summarizes recent progress with currently available therapies and—on the basis of present immunopathogenetic concepts—outlines future treatment strategies. Muscle Nerve 30: 131–136, 2004
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.20076