Multicenter evaluation of a whole-blood filter that saves platelets

• Published in: Transfusion (Philadelphia, Pa.) Pa.), 2004-08, Vol.44 (8), p.1197-1203
• Main Authors: Paunovic, Dragica, Van Der Meer, Pieter, Kjeldsen-Kragh, Jens, Kekomaki, Riitta, Larsson, Stella, Greppi, Noemi, Porretti, Laura, Balint, Bela, Trkuljic, Miroljub, Nedeljkovic, Ninoslav, Simonovic, Ruzica, Massaro, Anna, Labanca, Luciana, Kora, Shinichi, Riggert, Joachim
• Format: Article
• Language: English
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood Component Removal - instrumentation; Blood Platelets; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Filtration - methods; Humans; Leukocytes; Medical sciences; Transfusions. Complications. Transfusion reactions. Cell and gene therapy
• ISSN: 0041-1132; 1537-2995
• DOI: 10.1111/j.1537-2995.2004.03350.x

BACKGROUND:  Whole‐blood (WB) leukoreduction filters in current use retain the majority of PLTs. A new whole‐blood filter, which retains significantly fewer of the PLTs (or saves PLTs [WB‐SP]), has been developed. The performance characteristics of the WB‐SP filter have been evaluated in a multicenter study. STUDY DESIGN AND METHODS:  A total of 617 units of WB was collected into quadruple bag sets with an integrated WB‐SP filter, leukoreduced, and processed into leukoreduced RBCs (LR‐RBC), plasma (LR‐PL), and buffy coats (LR‐BC) from which, pooled, leukoreduced, PLT concentrates (LR‐PCs) were produced. Recovery, yield, and residual WBCs were assessed in prepared blood components. RESULTS:  The median residual WBC number in the LR‐RBCs was 0.05 × 106 (range,