Gelatin-coated magnetic iron oxide nanoparticles as carrier system: Drug loading and in vitro drug release study

Magnetic iron oxide nanoparticles (IOPs) were coated with gelatin A and B and drug-loading efficiency was investigated using doxorubicin (DXR) as a model drug to evaluate their potential as a carrier system for magnetic drug targeting. Drug loading to coated IOPs was done using adsorption as well as...

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Bibliographic Details
Published in:International journal of pharmaceutics 2009-01, Vol.365 (1), p.180-189
Main Authors: Gaihre, Babita, Khil, Myung Seob, Lee, Douk Rae, Kim, Hak Yong
Format: Article
Language:English
Subjects:
Acetone - chemistry
Animals
Antibiotics, Antineoplastic - administration & dosage
Biological and medical sciences
Cattle
Chemistry, Pharmaceutical
Coating
Cross-Linking Reagents - chemistry
Doxorubicin - administration & dosage
Doxorubicin hydrochloride
Drug Delivery Systems
Encapsulation efficiency
Ferric Compounds - chemistry
Gelatin
Gelatin - chemistry
General pharmacology
Glutaral - chemistry
Hydrogen-Ion Concentration
Magnetic iron oxide
Magnetics
Medical sciences
Nanoparticles
pH responsive drug release
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Static Electricity
Swine
Technology, Pharmaceutical
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Summary:Magnetic iron oxide nanoparticles (IOPs) were coated with gelatin A and B and drug-loading efficiency was investigated using doxorubicin (DXR) as a model drug to evaluate their potential as a carrier system for magnetic drug targeting. Drug loading to coated IOPs was done using adsorption as well as desolvation/cross-linking techniques to understand their role. Drug loading by adsorption technique was done by incubating mixture of coated IOPs and drug in various conditions of pH, DXR-to-coated IOPs ratio, gelatin types and IOPs amounts. Drug loading by desolvation/cross-linking technique was done by adding acetone and glutaraldehyde (GTA) to the mixture of coated IOPs and DXR. The results indicated involvement of electrostatic interaction during loading of DXR-to-coated IOPs. Compared to adsorption technique, desolvation/cross-linking technique improved the efficiency of drug loading regardless of type of gelatin used for the coating. The DXR-loaded particles showed pH responsive drug release leading to accelerate release of drug at pH 4 compared to pH 7.4.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2008.08.020